Associate Professor of Pediatrics (Neonatology),
with tenure
Chief, Division of Neonatology
State University of New York at Buffalo
Children's Hospital of Buffalo

Phone: (716) 878-7687
Lab: (716) 829-2711
Fax: (716) 878-7945
E-Mail: rryan@upa.chob.edu

Special Interests:
Dr. Ryan's research is primarily directed to the potential role for growth factors in the repair of the alveolar epithelium after lung injury. Dr. Ryan recently has focused on the effects of several specific growth factors including keratinocyte growth factor (KGF) and transforming growth factor alpha (TGF-alpha) on alveolar repair. Specifically, Dr. Ryan is utilizing three models involving hyperoxic lung injury in newborn rabbits, ventilator induced lung injury in chronically ventilated premature sheep and a temporally-inducible transgenic mouse model of KGF receptor blockage to study type II cell proliferation during lung repair. Dr. Ryan's clinical research interests include neonatal ventilation, post-PPHN systemic hypertension, thrombolytic gene variants, breastfeeding and formula feeding effects, and neonatal Candida colonization and disease.

Undergraduate:
BA in Mathematical Sciences
The Johns Hopkins University, Baltimore, Maryland

Medical School:
MD, State University of New York
Upstate Medical Center, Syracuse, New York

Pediatric Residency:
State University of New York, Upstate Medical Center
Syracuse, New York

Neonatal-Perinatal Medicine Fellowship:
University of Cincinnati and Children's Hospital Medical Center
Cincinnati, Ohio

Professional Organizations:
American Academy of Pediatrics
American Thoracic Society
Society for Pediatric Research
American Physiological Society
Perinatal Research Society

Recent Publications:

D'Angio CT, Maniscalco WM, Ryan RM, Avissar NE, Basavegowda K, Sinkin RA. Vascular endothelial growth factor (VEGF) in pulmonary lavage fluid from premature infants: Effects of age and postnatal dexamethasone. Biology of the Neonate 76(5):266-73, 1999.

D'Angio CT, LoMonaco MB, Chaudhry SA, Ryan RM. Discordant pulmonary proinflammatory cytokine expression during acute hyperoxia in the newborn rabbit lung. Exp Lung Res, 25:443-465, 1999.

Hastings RH, Ryan RM, D'Angio CT, Holm BA, Patel A, Quintana R, Biederman E, Burton DW, Deftos LJ. Parathyroid hormone-related protein response to hyperoxic lung injury. Am J Physiol:Lung Cell Mol Physiol 282(6):L1198-208, 2002.

Waheed S, D'Angio CT, Wagner CL, Madtes DK, Finkelstein JN, Paxhia A, Ryan RM. Transforming growth factor alpha (TGF-alpha) is increased during hyperoxia and fibrosis. Exp Lung Res, 28:361-372, 2002.

D'Angio CT, Sinkin RA, Stevens TP, Landfish NK, Merzbach JL, Ryan RM, Phelps DL, Palumbo DR, Myers GJ. Longitudinal fifteen-year follow-up of children born below 29 weeks' gestation following introduction of surfactant therapy into a region: neurological, cognitive and educational outcomes. Pediatrics, in press.